Research on Ashwagandha ...
Several Ashwagandha researches have been done in India regarding Ashwagandha and its contraceptive effects.
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Effect of Withania somnifera on CTL activity, By-Davis L, Kuttan G.
Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
The stimulatory effect of Withania somnifera on cytotoxic T lymphocytes was determined in Balb/C mice by the Winn's Neutralization assay using CTL sensitive EL4 thymoma cells as target cells. These studies indicate that Withania somnifera could stimulate the generation of cytotoxic T lymphocyte and it may reduce tumour growth.
Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice. By-Prakash J, Gupta SK, Dinda AK.
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India.
The chemopreventive effect of Withania somnifera hydroalcoholic root extract (WSRE) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin cancer was investigated in Swiss albino mice. The results of the study revealed a significant decrease in incidence and average number of skin lesions in mice. From the present study, it can be inferred that WRSE possesses potential chemopreventive activity in this experimental model of cancer. The chemopreventive activity may be linked to the antioxidant/free radical-scavenging constituents of the extract. The anti-inflammatory and immunomodulatory properties of WSRE are also likely to contribute to its chemopreventive action.
Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. By-Agarwal R, Diwanay S, Patki P, Patwardhan B.
Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, India.
A significant increase in white blood cell counts and platelet counts was observed in animals treated with WST. A protective effect in cyclophosphamide-induced myelosuppression was observed in animals treated with WST and WS2, revealing a significant increase in white blood cell counts and platelet counts. Cyclophosphamide-induced immunosuppression was counteracted by treatment with WS2, revealing significant increase in hemagglutinating antibody responses and hemolytic antibody responses towards sheep red blood cells.
Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.
Indian J Exp Biol. 2000 Jun;38(6):607-9.
Six mild NIDDM subjects and six mild hypercholesterolemic human subjects were treated with the powder of roots of ashwagandha for 30 days.
Conclusion: Suitable parameters were studied in the blood and urine samples of the subjects along with dietary pattern before and at the end of treatment period.Significant decrease in serum cholesterol, triglycerides, LDL (low density lipoproteins) and VLDL (very low density lipoproteins) cholesterol were observed indicating that root of ashwagandha is a potential source of hypoglycemic, diuretic and hypocholesterolemic agents.
Axon or dendrite predominant outgrowth induced by constituents from Ashwagandha.
Kuboyama T. Neuroreport. 2002 Oct 7;13(14):1715-20.
We previously reported that the methanol extract of Ashwagandha induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells.
Conclusion: The results suggest that axons are predominantly extended by withanolide A, and dendrites by withanosides IV and VI.
Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications.
Drug Metabol Drug Interact. 2003;19(3):211-22.
Conclusion: Ashwagandha inhibited both the lipid peroxidation and protein oxidative modification induced by copper. These effects were similar to those of superoxide dismutase and mannitol. The results indicate the therapeutic potential of Ashwagandha in aging and copper-induced pathophysiological conditions.
Cardioprotection from ischemia and reperfusion injury by Withania somnifera (ashwagandha): a hemodynamic, biochemical and histopathological assessment.
Mol Cell Biochem. 2004 May;260(1-2):39-47.
The efficacy of Withania somnifera to limit myocardial injury after ischemia and reperfusion was explored and compared to that of Vitamin E.
Conclusion: Results indicate that ashwagandha significantly reduced myocardial injury and emphasize the beneficial action of ashwagandha as a cardioprotective agent.
Scientific basis for the therapeutic use of Withania somnifera: a review.
Altern Med Rev. 2000 Aug;5(4):334-46. Mishra LC, Singh BB, Dagenais S. Los Angeles College of Chiropractic Whittier, CA
The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity.
Conclusion: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity. These results are very encouraging and indicate this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Clinical trials using ashwagandha for a variety of conditions should also be conducted.
More information can be obtained from: www.raysahelian.com/ashwagandha.html
News & Research :
Ashwagandha (Withania somniferum) - Healthwell.com
Ashwagandha safety checker - Healthwell.com
Ashwagandha (Withania somniferum) - The Natural Pharmacist
Stress: The Hidden Factor For Weight Gain - Natural Foods Merchandiser, 4/02
A proven sex-drive enhancer? - Dr. Weil, 9/20/00
Ashwaganda for Sexual Stamina? - Dr. Weil, 6/14/99
Detailed information can be obtained at: http://qualitycounts.com/fpashwaganda.html
Cancer Chemotherapy - J Ethnopharmacol. 2004.
Reduced Tumor Growth / Life Expansion - J Exp Clin Cancer Res. 2002.
Skin Cancer - Nutr Cancer. 2002.
Immunomodulatory Activity - J Ethnopharmacol. 1999.
Cell Mediated Immune Responses
Ref at: http://healthyherbs.about.com/cs/monographs/p/Ashwagandha.htm
Some more informations on the research done on Ashwagandha and various articles published can be browsed throughthese links :
These researches were done successfully with the appropriate result.